Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants.

نویسندگان

  • H Daniell
  • S J Streatfield
  • K Wycoff
چکیده

The use of plants for medicinal purposes dates back thousands of years but genetic engineering of plants to produce desired biopharmaceuticals is much more recent. As the demand for biopharmaceuticals is expected to increase, it would be wise to ensure that they will be available in significantly larger amounts, on a cost-effective basis. Currently, the cost of biopharmaceuticals limits their availability. Plant-derived biopharmaceuticals are cheap to produce and store, easy to scale up for mass production, and safer than those derived from animals. Here, we discuss recent developments in this field and possible environmental concerns.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Health Positive Uses of Genetically Modified Food Crops as a Source of

Molecular farming, or bio-pharming, has recently received much of attention for production of valuable recombinant proteins, with a few already being marketed. The use of whole plants for synthesis of pharmaceutical proteins offers various advantages in economy, scalability and safety over conventional production systems. GM plants are suitable for the inexpensive production of large amounts of...

متن کامل

Health Positive Uses of Genetically Modified Food Crops as a Source of

Molecular farming, or bio-pharming, has recently received much of attention for production of valuable recombinant proteins, with a few already being marketed. The use of whole plants for synthesis of pharmaceutical proteins offers various advantages in economy, scalability and safety over conventional production systems. GM plants are suitable for the inexpensive production of large amounts of...

متن کامل

Molecular farming of Plant Derived Edible Vaccines

Plant Derived Edible Vaccines Abstract Vaccines have been one of the most farreaching and important public health initiatives of the 20 century. Edible vaccine, in particular, might overcome some of the difficult of production, distribution and delivery associated with traditional vaccine. Transgenic potatoes expressing LT-B were found to induce both serum and secretory antibodies when fed to m...

متن کامل

Plant-based expression systems for protein and antimicrobial peptide production

Molecular farming technology offers a unique advantage that almost any protein can be produced economically and safely under very controlled conditions. Besides traditional production systems, such as bacteria, yeasts, insects and mammal cell lines, plants can now be used to produce eukaryotic recombinant proteins, especially therapeutic ones. Their advantages as hosts for protein production in...

متن کامل

Production of Biopharmaceuticals, Antibodies and Edible Vaccines in Transgenic Plants

The use of plants and other botanicals as a source of medicines exists of the earliest stages of civilization. Despite great advances in synthetic organic chemistry, it is estimated that about onefourth of present day prescription drugs still have a botanical origin. Recently, and through modern biotechnology, there has been a revival of interest in obtaining new pharmaceuticals from botanical ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Trends in plant science

دوره 6 5  شماره 

صفحات  -

تاریخ انتشار 2001